Main Street Bank was founded in June 2001, and they are proud that their bank is locally owned and managed. They know that a locally based bank staffed by seasoned banking professionals has a greater understanding of what local people need. Banks customers know that the best bankers in the Ohio Valley work at Main Street Bank. Bank’s located on the first floor of the Main Street Bank Building, 2001 Main Street in Wheeling and 1010 Commerce Street in Wellsburg, West Virginia.